Johnny Depp seems to be in the wrong place. Angelina Jolie has a weird English accent and talks in whispers. He is flustered because everyone is out to get him and the reason only Angelina seems to know.
The Tourist is the next film from the director Florian Henckel von Donnersmarck, who is known for his Oscar winning film The Lives of Others. He seems to have lost his bearings in this one.
In this clip the two of them are stuck on a boat with no driver. They are trying to figure out why they are their right now.